So I made it to the level 11 season and everything has gone to hell. My RB always starts out running untouched for a TD and then on other drives fumbles every single time.
Now my RB and QB always get hurt every single game. Most of the time for 6 weeks. I ran through all of my medi paks. I even bought a new RB who was maxed to 90 at everything and he got hurt for 6 weeks on his second carry of the game. All my players have maxed toughness.
What am I missing ?

I can only advice you to check your rythm level and the energy level of players.

So a few things 1st check Rhythm..
. Toughness...you always want maxed

But another thing people tend to do is over use a player.. they make 1-2 plays run just the wishbone and hand the same player the ball every down or every other down.. your players get tired there stats drop.. including Toughness....just like in real life.. if a NFL teams handed the ball to the same guy every down.. well he is gonn run out of gas.. In this game it seems to happen very fast.. I think your prob over using your guys by the sounds of it.. Although you also said your QB is getting hurt... so it could be a setting problem with rythem .... or both Look up lehigh Valley Outlawz in game.... play me and I'll be happy to help.. just let me know your team name.. so i know to look for you